Publications

LeMerise, L.G., Guerrero‐Gonzalez, J.M., McVea, A., Zammit, M., Kecskemeti, S., Hartley, S., Head, E., Mapstone, M., Handen, B., Alexander, A., Christian, B. (2025) Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome. Alzheimer’s Dement. 21:e70572. https://doi.org/10.1002/alz.70572
Guerrero-Gonzalez, J. M., Kirk, G. R., Birn, R., Bigler, E. D., Bowen, K., Broman, A. T., Rosario, B. L., Butt, W., Beers, S. R., Bell, M. J., Alexander, A. L., Ferrazzano, P. A., & ADAPT MRI Biomarkers Investigators (2024). Multi-modal MRI of hippocampal morphometry and connectivity after pediatric severe TBI. Brain imaging and behavior, 18(1), 159–170. https://doi.org/10.1007/s11682-023-00818-x
Surgent, O., Riaz, A., Ausderau, K. K., Adluru, N., Kirk, G. R., Guerrero-Gonzalez, J., Skaletski, E. C., Kecskemeti, S. R., Dean Iii, D. C., Weismer, S. E., Alexander, A. L., & Travers, B. G. (2022). Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children. Molecular autism, 13(1), 48. https://doi.org/10.1186/s13229-022-00524-3
DiPiero, M. A., Surgent, O. J., Travers, B. G., Alexander, A. L., Lainhart, J. E., & Dean Iii, D. C. (2022). Gray matter microstructure differences in autistic males: A gray matter based spatial statistics study. NeuroImage. Clinical, 37, 103306. Advance online publication. https://doi.org/10.1016/j.nicl.2022.103306

Moody, J. F., Dean, D. C., 3rd, Kecskemeti, S. R., Blennow, K., Zetterberg, H., Kollmorgen, G., Suridjan, I., Wild, N., Carlsson, C. M., Johnson, S. C., Alexander, A. L., & Bendlin, B. B. (2022). Associations between diffusion MRI microstructure and cerebrospinal fluid markers of Alzheimer’s disease pathology and neurodegeneration along the Alzheimer’s disease continuum. Alzheimer’s & dementia (Amsterdam, Netherlands), 14(1), e12381. https://doi.org/10.1002/dad2.12381
Planalp, E. M., Dowe, K. N., Alexander, A. L., Goldsmith, H. H., Davidson, R. J., & Dean, D. C., 3rd (2022). White matter microstructure predicts individual differences in infant fear (But not anger and sadness). Developmental science, e13340. Advance online publication. https://doi.org/10.1111/desc.13340
Guerrero-Gonzalez, J. M., Yeske, B., Kirk, G. R., Bell, M. J., Ferrazzano, P. A., & Alexander, A. L. (2022). Mahalanobis distance tractometry (MaD-Tract) – a framework for personalized white matter anomaly detection applied to TBI. NeuroImage, 260, 119475. https://doi.org/10.1016/j.neuroimage.2022.119475
Birn, R. M., Dean, D. C., 3rd, Wooten, W., Planalp, E. M., Kecskemeti, S., Alexander, A. L., Goldsmith, H. H., & Davidson, R. J. (2022). Reduction of motion artifacts in functional connectivity resulting from infrequent large motion. Brain Connectivity, 12(8), 740–753. https://doi.org/10.1089/brain.2021.0133
Prigge, M., Bigler, E. D., Lange, N., Morgan, J., Froehlich, A., Freeman, A., Kellett, K., Kane, K. L., King, C. K., Taylor, J., Dean, D. C., 3rd, King, J. B., Anderson, J. S., Zielinski, B. A., Alexander, A. L., & Lainhart, J. E. (2022). Longitudinal stability of intellectual functioning in autism spectrum disorder: From age 3 through mid-adulthood. Journal of Autism and Developmental Disorders, 52(10), 4490–4504. https://doi.org/10.1007/s10803-021-05227-x
Grupe, D. W., Barnes, A. L., Gresham, L., Kirvin-Quamme, A., Nord, E., Alexander, A. L., Abercrombie, H. C., Schaefer, S. M., & Davidson, R. J. (2022). Perceived stress associations with hippocampal-dependent behavior and hippocampal subfield volume. Neurobiology of Stress, 19, 100469. https://doi.org/10.1016/j.ynstr.2022.100469
Ferguson, N. M., Rebsamen, S., Field, A. S., Guerrero, J. M., Rosario, B. L., Broman, A. T., Rathouz, P. J., Bell, M. J., Alexander, A. L., Ferrazzano, P. A., & ADAPT MRI Investigators (2022). Magnetic Resonance Imaging Findings in Infants with Severe Traumatic Brain Injury and Associations with Abusive Head Trauma. Children (Basel, Switzerland), 9(7), 1092. https://doi.org/10.3390/children9071092
Knussmann, G. N., Anderson, J. S., Prigge, M., Dean, D. C., 3rd, Lange, N., Bigler, E. D., Alexander, A. L., Lainhart, J. E., Zielinski, B. A., & King, J. B. (2022). Test-retest reliability of FreeSurfer-derived volume, area and cortical thickness from MPRAGE and MP2RAGE brain MRI images. Neuroimage. Reports, 2(2), 100086. https://doi.org/10.1016/j.ynirp.2022.100086
Moody, J. F., Aggarwal, N., Dean, D. C., 3rd, Tromp, D., Kecskemeti, S. R., Oler, J. A., Kalin, N. H., & Alexander, A. L. (2022). Longitudinal assessment of early-life white matter development with quantitative relaxometry in nonhuman primates. NeuroImage, 251, 118989. https://doi.org/10.1016/j.neuroimage.2022.118989
Guerrero-Gonzalez, J., Surgent, O., Adluru, N., Kirk, G. R., Dean Iii, D. C., Kecskemeti, S. R., Alexander, A. L., & Travers, B. G. (2022). Improving Imaging of the Brainstem and Cerebellum in Autistic Children: Transformation-Based High-Resolution Diffusion MRI (TiDi-Fused) in the Human Brainstem. Frontiers in integrative neuroscience, 16, 804743. https://doi.org/10.3389/fnint.2022.804743
Luo, Z., Adluru, N., Dean, D. C., 3rd, Alexander, A. L., & Goldsmith, H. H. (2022). Genetic and environmental influences of variation in diffusion MRI measures of white matter microstructure. Brain structure & function, 227(1), 131–144. https://doi.org/10.1007/s00429-021-02393-7
Bazydlo, A. M., Zammit, M. D., Wu, M., Lao, P. J., Dean, D. C., 3rd, Johnson, S. C., Tudorascu, D. L., Cohen, A., Cody, K. A., Ances, B., Laymon, C. M., Klunk, W. E., Zaman, S., Handen, B. L., Hartley, S. L., Alexander, A. L., & Christian, B. T. (2022). White matter microstructure associations to amyloid burden in adults with Down syndrome. NeuroImage. Clinical, 33, 102908. https://doi.org/10.1016/j.nicl.2021.102908
Vogt, N. M., Hunt, J., Adluru, N., Ma, Y., Van Hulle, C. A., Doug III, D., Kecskemeti, S. R., Chin, N. A., Carlsson, C. M., Asthana, S., Johnson, S. C., Kollmorgen, G., Batrla, R., Wild, N., Buck, K., Zetterberg, H., Alexander, A. L., Blennow, K., & Bendlin, B. B. (2022). Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults. Alzheimer’s & dementia: the journal of the Alzheimer’s Association, 18(1):65-76. doi: 10.1002/alz.12364.
Zhou, X., Planalp, E. M., Heinrich, L., Pletcher, C., DiPiero, M., Alexander, A. L., Litovsky, R. Y., & Dean, D. C., 3rd (2022). Inhibitory Control in Children 4-10 Years of Age: Evidence From Functional Near-Infrared Spectroscopy Task-Based Observations. Frontiers in human neuroscience, 15, 798358. https://doi.org/10.3389/fnhum.2021.798358
Fleming, V., Piro-Gambetti, B., Patrick, A., Zammit, M., Alexander, A., Christian, B. T., Handen, B., Cohen, A., Klunk, W., Laymon, C., Ances, B. M., Plante, D. T., Okonkwo, O., & Hartley, S. L. (2021). Physical activity and cognitive and imaging biomarkers of Alzheimer’s disease in down syndrome. Neurobiology of aging, 107, 118–127. https://doi.org/10.1016/j.neurobiolaging.2021.07.016
Kecskemeti, S., Freeman, A., Travers, B. G., & Alexander, A. L. (2021). FreeSurfer based cortical mapping and T1-relaxometry with MPnRAGE: Test-retest reliability with and without retrospective motion correction. NeuroImage, 242, 118447. https://doi.org/10.1016/j.neuroimage.2021.118447
Peterson, M., Prigge, M., Bigler, E. D., Zielinski, B., King, J. B., Lange, N., Alexander, A., Lainhart, J. E., & Nielsen, J. A. (2021). Evidence for normal extra-axial cerebrospinal fluid volume in autistic males from middle childhood to adulthood. NeuroImage, 240, 118387. https://doi.org/10.1016/j.neuroimage.2021.118387
Fleming, V., Piro-Gambetti, B., Bazydlo, A., Zammit, M., Alexander, A. L., Christian, B. T., Handen, B., Plante, D. T., & Hartley, S. L. (2021). Sleep and White Matter in Adults with Down Syndrome. Brain sciences, 11(10), 1322. https://doi.org/10.3390/brainsci11101322
Moody, J. F., Adluru, N., Alexander, A. L., & Field, A. S. (2021). The Connectomes: Methods of White Matter Tractography and Contributions of Resting State fMRI. Seminars in ultrasound, CT, and MR, 42(5), 507–522. https://doi.org/10.1053/j.sult.2021.07.007
Prigge, M., Lange, N., Bigler, E. D., King, J. B., Dean, D. C., 3rd, Adluru, N., Alexander, A. L., Lainhart, J. E., & Zielinski, B. A. (2021). A 16-year study of longitudinal volumetric brain development in males with autism. NeuroImage, 236, 118067. https://doi.org/10.1016/j.neuroimage.2021.118067
Ferrazzano, P., Yeske, B., Mumford, J., Kirk, G., Bigler, E. D., Bowen, K., O’Brien, N., Rosario, B., Beers, S. R., Rathouz, P., Bell, M. J., & Alexander, A. L. (2021). Brain Magnetic Resonance Imaging Volumetric Measures of Functional Outcome after Severe Traumatic Brain Injury in Adolescents. Journal of neurotrauma, 38(13), 1799–1808. https://doi.org/10.1089/neu.2019.6918
Surgent, O., Dean, D. C., Alexander, A. L., Dadalko, O. I., Guerrero-Gonzalez, J., Taylor, D., Skaletski, E., & Travers, B. G. (2021). Neurobiological and behavioural outcomes of biofeedback-based training in autism: a randomized controlled trial. Brain communications, 3(3), fcab112. https://doi.org/10.1093/braincomms/fcab112
HashemizadehKolowri, S. K., Chen, R. R., Adluru, G., Dean, D. C., Wilde, E. A., Alexander, A. L., & DiBella, E. (2021). Simultaneous multi-slice image reconstruction using regularized image domain split slice-GRAPPA for diffusion MRI. Medical image analysis, 70, 102000. https://doi.org/10.1016/j.media.2021.102000
Aggarwal, N., Moody, J. F., Dean, D. C., Tromp, D., Kecskemeti, S. R., Oler, J. A., Alexander, A. L., & Kalin, N. H. (2021). Spatiotemporal dynamics of nonhuman primate white matter development during the first year of life. NeuroImage, 231, 117825. https://doi.org/10.1016/j.neuroimage.2021.117825
Dowe, K. N., Planalp, E. M., Dean, D. C., 3rd, Alexander, A. L., Davidson, R. J., & Goldsmith, H. H. (2020). Early microstructure of white matter associated with infant attention. Developmental cognitive neuroscience, 45, 100815. https://doi.org/10.1016/j.dcn.2020.100815
Liu Y, Nacewicz BM, Zhao G, Adluru N, Kirk GR, Ferrazzano PA, Styner MA, Alexander AL. (2020) A 3D Fully Convolutional Neural Network With Top-Down Attention-Guided Refinement for Accurate and Robust Automatic Segmentation of Amygdala and Its Subnuclei. Frontiers in Neuroscience. 14:260. doi: 10.3389/fnins.2020.00260. PMID: 32508558; PMCID: PMC7253589.
Vogt NM, Hunt JF, Adluru N, Dean DC, Johnson SC, Asthana S, Yu JJ, Alexander AL, Bendlin BB. (2020). Cortical Microstructural Alterations in Mild Cognitive Impairment and Alzheimer’s Disease Dementia. Cerebral Cortex, 30(5):2948-2960. doi: 10.1093/cercor/bhz286.
Kecskemeti S, Alexander AL. (2020). Three-dimensional motion-corrected T₁ relaxometry with MPnRAGE. Magnetic Resonance in Medicine 2020 Apr 17. doi: 10.1002/mrm.28283. Epub ahead of print. PMID: 32301173.
Kecskemeti SR, Alexander AL. (2020). Test-retest of automated segmentation with different motion correction strategies: A comparison of prospective versus retrospective methods. Neuroimage. 2020 Apr 1;209:116494. doi: 10.1016/j.neuroimage.2019.116494. Epub 2019 Dec 30. PMID: 31899289; PMCID: PMC7056555.
Guerrero JM, Adluru N, Bendlin BB, Goldsmith HH, Schaefer SM, Davidson RJ, Kecskemeti SR, Zhang H, Alexander AL. (2019). Optimizing the intrinsic parallel diffusivity in NODDI: An extensive empirical evaluation. PLoS One. 14(9):e0217118. doi: 10.1371/journal.pone.0217118.
Green, R. R., Bigler, E. D., Froehlich, A., Prigge, M., Zielinski, B. A., Travers, B. G., Anderson, J. S., Alexander, A., Lange, N., & Lainhart, J. E. (2019). Beery VMI and Brain Volumetric Relations in Autism Spectrum Disorder. Journal of pediatric neuropsychology, 5(3), 77–84. https://doi.org/10.1007/s40817-019-00069-z
King JB, Prigge MBD, King CK, Morgan J, Weathersby F, Fox JC, Dean DC 3rd, Freeman A, Villaruz JAM, Kane KL, Bigler ED, Alexander AL, Lange N, Zielinski B, Lainhart JE, Anderson JS. (2019). Generalizability and reproducibility of functional connectivity in autism. Molecular Autism, 24;10:27. doi: 10.1186/s13229-019-0273-5.
Adluru N, Luo Z, Van Hulle CA, Schoen AJ, Davidson RJ, Alexander AL, Goldsmith HH. (2019). Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach. Science Reports, 18;7(1):8749. PMID: 28821748. PMCID: PMC5562810. DOI: 10.1038/s41598-017-08107-6
Birn RM, Converse AK, Rajala AZ, Alexander AL, Block WF, McMillan AB, Christian BT, Filla CN, Murali D, Hurley SA, Jenison RL, Populin LC. (2019). Changes in endogenous dopamine induced by methylphenidate predict functional connectivity in non-human primates. Journal of Neuroscience, 39(8):1436-1444. doi: 10.1523/JNEUROSCI.2513-18.2018.
Ferrazzano PA, Rosario BL, Wisniewski SR, Shafi NI, Siefkes HM, Miles DK, Alexander AL, Bell MJ; Investigators of the ADAPT Trial. (2019). Use of magnetic resonance imaging in severe pediatric traumatic brain injury: assessment of current practice. Journal of Neurosurgery Pediatrics, 8:1-9. doi: 10.3171/2018.10.PEDS18374.
Rowley PA, Guerrero-Gonzalez J, Alexander AL, Yu JJ. (2019). Convergent microstructural brain changes across genetic models of autism spectrum disorder-A pilot study. Psychiatry Research Neuroimaging, 30;283:83-91. doi: 10.1016/j.pscychresns.2018.12.007.
Kecskemeti S, Samsonov A, Velikina J, Field AS, Turski P, Rowley H, Lainhart JE, Alexander AL. (2018). Robust Motion Correction Strategy for Structural MRI in Unsedated Children Demonstrated with Three-dimensional Radial MPnRAGE. Radiology, 289(2):509-516. doi: 10.1148/radiol.2018180180. Epub 2018 Jul 31.
Pozorski V, Oh JM, Adluru N, Merluzzi AP, Theisen F, Okonkwo O, Barzgari A, Krislov S, Sojkova J, Bendlin BB, Johnson SC, Alexander AL, Gallagher CL. (2018). Longitudinal white matter microstructural change in Parkinson’s disease. Human Brain Mapping, 39(10):4150-4161. doi: 10.1002/hbm.24239.
Prigge MBD, Bigler ED, Travers BG, Froehlich A, Abildskov T, Anderson JS, Alexander AL, Lange N, Lainhart JE, Zielinski BA. (2018). Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 48(10):3319-3329. doi: 10.1007/s10803-018-3566-1.
Dean DC 3rd, Planalp EM, Wooten W, Kecskemeti SR, Adluru N, Schmidt CK, Frye C, Birn RM, Burghy CA, Schmidt NL, Styner MA, Short SJ, Kalin NH, Goldsmith HH, Alexander AL, Davidson RJ. (2019). Association of Prenatal Maternal Depression and Anxiety Symptoms With Infant White Matter Microstructure. JAMA Pediatrics, 172(10):973-981. PMID: 30177999. PMCID: PMC6190835. DOI: 10.1001/jamapediatrics.2018.2132
McLaughlin K, Travers BG, Dadalko OI, Dean DC 3rd, Tromp D, Adluru N, Destiche D, Freeman A, Prigge MD, Froehlich A, Duffield TC, Zielinski BA, Bigler ED, Lange N, Anderson JS, Alexander AL, Lainhart JE. (2018). Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder. Autism Research, 11(3):450-462.
Ong IM, Gonzalez JG, McIlwain SJ, Sawin EA, Schoen AJ, Adluru N, Alexander AL, Yu JJ. (2018). Gut microbiome populations are associated with structure-specific changes in white matter architecture. Translational Psychiatry. 8(1):6. doi: 10.1038/s41398-017-0022-5.
Dean DC 3rd, Planalp EM, Wooten W, Schmidt CK, Kecskemeti SR, Frye C, Schmidt NL, Goldsmith HH, Alexander AL, Davidson RJ. (2018). Investigation of brain structure in the 1-month infant. Brain Structure and Function, 223(4):1953-1970. doi: 10.1007/s00429-017-1600-2.